ISES 2014 International Society of Exposure Science Conference

Cincinnati, OH – 12 October, 2014 to 16 October, 2014

ISES is one of the most important conferences for Creme Global each year. The theme of this year's conference is Exposure Science Integration to Protect Ecological Systems, Human Well-Being, and Occupational Health. The program will foster the integration of exposure science as applied to community, occupational, and ecological health as recommended by the NRC Exposure Science in the 21st Century.

Creme Global will be disseminating their latest research in three presentations at the conference. The presentation slides will be available to download here after the conference.

     Dr. Damien Comiskey, Expert Modelling & Statistics at Creme Global, will present:

Novel databases for exposure to cosmetics and personal care products
(Plenary 2: Hall of Mirrors, Monday 13th October, 9-10am)

Description of Presentation:
In this presentation, the authors will present robust databases available on consumer product uses and how the data can be used to facilitate population based exposure assessments.

Exposure of cosmetics and personal care products to the population can only be determined by way of a detailed and robust survey. The frequency and combinations of products used at specific times during the day will allow the calculation of aggregate exposure for an individual consumer, and to the sample population. In the present study, habits and practices of personal care and cosmetic products have been obtained from market research data for 36,446 subjects across European countries and the United States. Each subject logged their product uses, time of day and body application sites in an online diary for seven consecutive days. Each subject’s likely amount of product used per occasion was probabilistically estimated based on their demographic and data from the literature. Furthermore, each subject’s likely weight and body surface areas could also be approximated using anthropometric modelling also based on demographics. Using known product dermal retention factors, the chemical exposure was estimated based on Monte Carlo simulations. Statistical analyses of the habits and practices and chemical exposure are presented, which show the robustness of the data and the ability to estimate aggregate exposure. Consequently, the data and models method presented show potential as a means of performing safety assessments on personal and cosmetics products.

                Cian O'Mahony, Head of Expert Modelling & Statistics at Creme Global, will present:

Aggregate Exposures to Fragrances in Consumer Products
(Plenary 2: Hall of Mirrors, Monday 13th October, 10.30-12pm)

Description of Presentation:  
Use of cosmetic and personal care products forms part of the daily routine for most people in almost every country in the world. Ensuring safety in the use of such products forms an integral step in product development and design, and in the regulation of the products. In this presentation, consumer exposure to common fragrances in consumer products using a novel aggregate exposure model is presented.

Fragrance materials are used in a variety of personal care products and cosmetics, which in turn are used in a variety of combinations and in different amounts by consumers. Consequently exposure to fragrances via the dermal and inhalation routes is a potential risk for consumers, and in particular the question of aggregate exposure due to multiple product use should be addressed. In order to assure the safe use of fragrances in personal care products and cosmetics, a robust methodology is required to that incorporates variability in both fragrance use levels in different products and in consumer habits and practices.  In conjunction with the Research Institute of Fragrance Materials (RIFM) and their membership, use level surveys were conducted to develop a database representative of fragrance concentrations in a wide variety of consumer products on the market. This database was linked to a probabilistic exposure model based on a novel database of consumer habits and practices in order to estimate the distribution of aggregate exposure to the fragrances in the US and European markets. The databases and model were also made incorporated into a cloud-based software tool containing the exposure estimates, having the ability to perform new exposure assessments based on different model assumptions and capable of assessing prospective exposure to new novel fragrance materials being brought to market.

Pesticide Exposure in Ireland: Rapid Response Models and Reporting Annual Exposure
(Plenary 2: Hall of Mirrors, Monday 13th October, 9-10am)

Approaches to estimating dietary exposure to pesticides in Ireland using residue data are presented. In particular, models for assessing MRL breaches and annually reporting of pesticide exposure assessment in Ireland is described.

Each year in Ireland, the Pesticide Control Division generate an annual report detailing exposure to pesticides in Irish consumers. Both probabilistic and deterministic assessments of dietary exposure are calculated, by linking residue data measured in the national sampling plan to national dietary surveys. Assessments are carried out using the dietary exposure system Creme Crop Sciences, a cloud-based software service incorporating both cumulative and aggregate probabilistic assessments of exposure to pesticides. The acute and chronic exposure models in Creme Crop Sciences are described, as well as a number of variability models, limit analyses based on toxicological endpoints, and the handling of residue data. Where non-compliant residues were detected, rapid risk assessments based on the residue level found and national food consumption data are carried out to estimate the risk to consumers and to guide the follow-up action to be taken. This is carried out using a specially developed feature called the “MRL Breach Wizard”, which can be used as a rapid-response type model to estimate if action is required should an MRL be exceeded.


Dr. Sarah Tozer, Procter & Gamble and Cian O'Mahony of Creme Global will present:

Aggregate Exposure to Aluminium from Diet, Personal Care Products, Cosmetics and Medications
(Plenary 2: Hall of Mirrors, Monday 13th October, 9-10am)

Aluminium is a ubiquitous substance and exposure to very high levels of Al have been linked to adverse health effects in humans, with JECFA assigning a Provisional Tolerable Weekly Intake (PTWI) of 2 mg/kg/week in 2012. Aluminium salts and aluminium lakes are used as functional ingredients in personal care products, cosmetics and medications, and aluminium occurs in most foods and drinking water to some extent. Consumers are therefore exposed to aluminium from a number of routes, with exposure in the population being highly variable due to differences in consumer habits and practices resulting from differing dietary patterns and the usage of medications, personal care products and cosmetics. The aim of this study is to characterise the distribution of exposure in different consumer populations and to assess the relative contributions of the different sources of exposure.  A probabilistic model characterising the different routes of exposure was developed, taking into account the variability in consumer habits and practices and the occurrence and concentrations of aluminium in different foods and consumer products. Dermal absorption and oral ingestion and the related concepts of dermal penetration and bioavailability are considered in order to combine exposures from different routes.

If you are attending this year’s conference, please contact us to arrange a meeting. You can read more about the event here